Incomplete genome annotation obstructs our understanding of cell function. Proteins with hypothetical annotation result from either an outdated database or insufficient experimental evidence. This session leads attendees through a bioinformatics project using several open-access, web-based programs to predict which hypothetical proteins are good candidates for laboratory characterization. This project is successfully used for assignments at high school and undergraduate levels, and science fair projects in middle school. Results from student projects improve public database annotation and are welcomed paper publications and scientific conference presentations. For maximum benefit, bring an electronic device with internet access. Instructions, rubrics, and training videos provided.
